Magnesium & Skin Health (Master Page)

Do you have acne, wrinkles or rapidly aging skin?

Our detoxification, hormone regulation, & anti-aging systems all need magnesium, and invasive skin treatments accelerate skin’s aging without magnesium supplementation.

++ Page Overview

This master page looks at why clear, firm, wrinkle-free skin depends on magnesium, followed by a solutions section to help you restore and maintain healthy magnesium levels.

  1. Magnesium prevents and fights acne and inflammation.
  2. Skin firmness and elasticity depend on magnesium.
  3. Magnesium supports our skin’s DNA.
  4. Magnesium powers vitamin D to keep our skin healthy.
  5. Invasive skin treatments deceptively accelerate skin aging without magnesium.

Before the solutions section, we look at how modern farming and stress levels have made it impossible to get enough magnesium from diet alone. 

++ Helpful tip

This page has a lot of powerful info to help you resolve your problems. 

If you’re busy or want to understand things better, please read each section’s quick summary.

1. Magnesium fights acne and inflammation:

Magnesium and acne

Acne rarely originates in our skin but is rather an indicator of inflammation throughout our body, which can also be expressed on our skin’s surface.[1-4]Inflammation arises when we experience stress and our body’s systems stop working optimally. Not only do these systems depend on magnesium[5-10], but magnesium itself has anti-inflammatory effects on the human body, thus reducing the major cause of acne. [11-13] 

In fact magnesium’s anti-inflammatory effects can be seen directly inside our sebocytes: the acne-prone skin cells which make our skin’s natural lubricant called sebum[14]. 

A rise in inflammation can cause an overproduction of sebum which allows bacteria such as Propionibacterium Acnes and Staphylococcus Epidermis to thrive. The mixture of these bacteria, excess sebum and dead skin cells clogs our pores and results in acne.

Magnesium & inflammation

We know magnesium fights inflammation in our skin cells, yet it also fights systemic inflammation throughout our entire body:

Blood tests use biomarkers to see the degree of Inflammation in our body. E-selectin is the biomarker that reveals inflammation in our skin and C-reactive protein identifies systemic inflammation in our body.

Taking magnesium lowers both E-selectin and C-reactive protein (15,16)reducing skin and whole-body inflammation. This makes sense when we look at magnesium’s role in producing our body’s most potent detoxifying agents:

Magnesium & detoxification

Our body’s innate systems protect our skin from oxidative stress and inflammation with the help of our two most potent antioxidants, glutathione & melatonin:

Glutathione is our most abundant anti-inflammatory helper. Our skin cells make it using a molecule called ATP: adenosine triphosphate.[17-20] which itself needs magnesium.  [21-25] Simply put, we need magnesium for the antioxidant benefits of glutathione.

Melatonin lets us sleep. This is essential for healthy skin because most of our skin’s regeneration happens during sleep. Melatonin is also a powerful antioxidant [26] which protects our skin’s DNA [27], and delays the death of our skin cells. [28]

Our body can’t make its own melatonin without magnesium, because the process once again requires ATP-Mg2+ (magnesium-dependent ATP)[29,30].  This helps explain why magnesium deficient diets result in lower levels of this rejuvenating antioxidant.[31]

1. Summary

The root cause of acne is linked to systemic inflammation in the body, which can cause special skin cells to produce excess sebum.

Magnesium helps with acne at the most fundamental level by preventing and fighting inflammation. 

Magnesium fights acne by making our two most powerful detox molecules: glutathione and melatonin.

2. Magnesium for young skin:

Magnesium for skin firmness & elasticity

Collagen and elastin are the two proteins that give our skin the firmness and elasticity it needs to look young and healthy. While there are different types of collagen and elastin used in different areas of our body (not just our skin), the one thing they all have in common is that none of them can be made without magnesium:

Our skin cells make collagen and elastin via a process called protein synthesis, where they use our DNA as an instruction manual to assemble amino acids into proteins such as collagen or elastin. This process has two phases, and both require magnesium:

Phase 1: Our DNA is unwound and the gene with the instructions to make collagen or elastin is located and duplicated. The enzymes that unwind the DNA (Helicases), and make a copy of the gene (RNA polymerases), both need magnesium to work. [32-40]

Phase 2: An enzyme called a ribosome now scans the new gene duplicate, and uses it to find the right amino acids and assemble them into collagen or elastin. The ribosome that performs this process is also magnesium-dependent. [41,42]

Without magnesium we cannot make the two proteins that maintain our skin’s firmness, elasticity and youth.

2. Summary

Collagen and elastin are the two proteins that give our skin its firmness and elasticity. Magnesium is needed for our body to produce both of them.

Magnesium is also needed for the function of the enzymes that repair our skin’s DNA daily: DNA Ligases.

Magnesium deficiency long-term can lead to accelerated skin aging.

3. Magnesium & our skin's DNA health

Magnesium & our skin’s DNA health

Our DNA holds the instructions for our cells to make collagen and elastin. Therefore it is critical that our DNA and genes be kept healthy at all times. This is why special enzymes called DNA ligases exist:

They constantly repair the damage that our DNA incurs from daily use and inflammation within the cell.[43,44] Our DNA ligases repair our DNA trillions of times per second.

None of our DNA ligases can function without magnesium.[45,46] Thus magnesium       deficiency can cause inadequate repair of the genes that let us make our skin’s elastin and collagen, which in turn leads to accelerated aging of our skin.

This increases the importance of how it has now become beryu difficult to satisfy daily magnesium requirements form diet alone:

3. Summary

Our DNA holds the instructions our skin cells use to make their collagen, elastin and other proteins to keep themselves healthy.

Magnesium is needed for the DNA ligase enzymes that repair our skin’s DNA 24/7 from daily damage. 

4. Vitamin D, skin repair & magnesium

Vitamin D is critical to the health and function of our skin (47) including reducing inflammation in our skin cells(48), immune system function, and our skin’s wound healing and regeneration(49).

However vitamin D production has three main stages, and all three depend on magnesium: 

The vitamin D we get from food or sunlight (whose UVB rays convert our cholesterol into Vitamin D), is in the inactive form [50,51]  known as D3 or cholecalciferol.[52]

Our liver then converts this inactive form into the storage form: calcidiol.

Our kidneys then convert this storage form into the final active form: calcitriol.

Without magnesium, our body can’t make active vitamin D because: the enzymes that facilitate the above conversions belong to the cytochrome P450 family of enzymes.[53-56] This family of enzymes is magnesium-dependent.[57]

Thus we see that magnesium’s role in vitamin D synthesis is critical for helping our skin recover from inflammation and other sources of stress such as light exposure.

4. Summary

Vitamin D is critical to maintaining our skin’s immunity, fighting inflammation, and ensuring propper wound healing and regeneration.

Vitamin D can only be synthesized from sunlight or cholesterol, and this synthesis requires magnesium.

5. Skin treatments age skin without magnesium:

Skin care experts know that invasive skin treatments improve our skin by first damaging it and then stimulating the body’s innate healing response, which is characterized by an increase in collagen and elastin production in our skin.

The goal of these treatments is for the increased collagen/elastin production to have a supercompensatory effect which improves the skin quality to a state that is better than it was before the treatment’s damage was incurred (otherwise the procedure serves no purpose).

However this only happens in an ideal world where our body has enough magnesium to satisfy both:

  1. The increased need of skin collagen/elastin production.
  2. All of our other vital functions of the body.

In a magnesium-deficient person, there is not enough magnesium to sustain both, which is where we find the problem.

How the damage is done

After the treatment, our nervous system signals our body to use more of our magnesium for the collagen/elastin production of our skin in order to repair it.

However at some point after the skin treatment (depending on the procedure and person) the body realizes that this skin damage is not a survival threat. At this point, if the person is magnesium deficient, then the increased prioritization of magnesium towards skin collagen/elastin stops, and goes back to more important vital functions.

If the amount of collagen/elastin made during this innate healing response was less than what was needed to fully repair the skin damage, the procedure has actually done more harm than good.

This can be deceptive because the initial increase in collagen/elastin production combined with the typical post-treatment swelling makes the skin look more full. This temporary improvement in appearance can lead us into a cycle of skin treatments (in a magnesium-deficient state) which accelerates the aging of our skin.

Invasive skin treatments can be very powerful and beneficial for making our skin look younger, because they do have the ability to increase the production of proteins that contribute to firm, elastic skin.  However this is only maximally possible in people who are not deficient in magnesium.

5. Summary

Invasive skin treatments cause damage to the skin in the hopes of stimulating a natural increase in collagen and elastin production.

However without enough magnesium, there is a chance that not enough of these proteins will be made, and that initially promising effects can fade into worse-looking skin.

6. Why Our Magnesium Levels Are Now Dropping:

Figure 1 is a general representation of the trends of the three primary factors that affect the magnesium levels in our body everyday. The fourth line represents our ability to make our own magnesium, which will always stay at zero.

  1. Total environmental stress that drains our magnesium
  2. Magnesium in our soil and healthy foods
  3. Our intestine’s ability to absorb magnesium from food and pills

Our adrenals (stress glands) are magnesium-dependent. Stress depletes magnesium, and inflames our intestine, hindering absorption of dietary magnesium. (Even a healthy gut only absorbs 30-40% of a food’s magnesium.)

This means our skin is competing for its magnesium not only with our other vital functions, but also with increasing amounts of environmental stress and poor intestinal Mg absorption.

A magnesium deficiency graph that shows how our magnesium intake has declined since 1950, while our sources of magnesium depletion have increased. The depletion of our soils and the increasing environmental stress show us that we can no longer get enough magnesium without supplementation. This strengthens the importance of magnesium for skin care.
A magnesium deficiency graph that shows how our magnesium intake has declined since 1950, while our sources of magnesium depletion have increased. The depletion of our soils and the increasing environmental stress show us that we can no longer get enough magnesium without supplementation. This strengthens the importance of magnesium for skin care.
  1. Total environmental stress that drains our magnesium
  2. Magnesium in our soil and healthy foods
  3. Our intestine’s ability to absorb magnesium from food and pills

Our adrenals (stress glands) are magnesium-dependent. Stress depletes magnesium, and inflames our intestine, hindering absorption of dietary magnesium. (Even a healthy gut only absorbs 30-40% of a food’s magnesium.)

This means our skin is competing for its magnesium not only with our other vital functions, but also with increasing amounts of environmental stress and poor intestinal Mg absorption.

Summary & Solutions:

Summary: Young, healthy skin depends on magnesium

Healthy, clear and young looking skin is simply not possible when we are deficient in magnesium:

  1. Magnesium detoxifies and fights inflammation and oxidative stress which cause acne.
  2. Our skin needs magnesium for its elasticity and firmness.
  3. The daily repair of our skin’s DNA is impossible without magnesium.
  4. Magnesium is needed for recovery after skin treatments and tanning via its connection to collagen, elastin, and vitamin D.

Due to our modern food supply’s deficiency in magnesium, to maintain naturally clear, firm and young skin for the long term, magnesium supplementation is recommended:

Solutions: Safe & smart magnesium restoration

To keep healthy magnesium levels and thus healthy skin, several measures should be taken:

  1. Take a natural, quality magnesium-chloride supplement to restore whole-body magnesium levels. This is the basis of any magnesium restoration protocol.
  2. Eat a magnesium-smart diet and avoid the tricky magnesium-rich foods.
  3. Do your best to reduce the environmental, psychological and physical factors that cause stress and thus deplete magnesium.
  4. Monitor your calcium intake. Calcium fortification in foods is widespread, and calcium supplementation while magnesium deficient causes inflammation.
  5. To help prevent other health conditions related to magnesium deficiency, use a secondary magnesium supplement with more specific effects for other body parts.

Click here to see the magnesium-chloride supplement we trust and recommend.

Click here to learn more about the other types of secondary supplements.

Click here to learn more about magnesium deficiency and the rest of your body parts.

++ References
  1. The role of inflammation in the pathogenesis of acne and acne scarring. http://www.ncbi.nlm.nih.gov/pubmed/16092795
  2. The sequence of inflammation, relevant biomarkers, and the pathogenesis of acne vulgaris: what does recent research show and what does it mean to the clinician? http://www.ncbi.nlm.nih.gov/pubmed/23986176
  3. What’s new in acne and inflammation? http://www.ncbi.nlm.nih.gov/pubmed/23839203
  4. Advances in the Understanding of the Pathogenesis of Inflammatory Acne.  http://www.ncbi.nlm.nih.gov/pubmed/26741394
  5. Magnesium in Man: Implications for Health and Disease  http://physrev.physiology.org/content/95/1/1.full
  6. Magnesium in Health and Disease  http://link.springer.com/chapter/10.1007%2F978-94-007-7500-8_3
  7. Magnesium basics  http://ckj.oxfordjournals.org/content/5/Suppl_1/i3.full
  8. BIOCHEMISTRY OF MAGNESIUM  http://www.uwm.edu.pl/jold/poj1532010/jurnal-16.pdf
  9. Magnesium Metabolism and its Disorders  http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1855626/
  10. Magnesium Deficiency: A Cause of Heterogenous Disease in Humans  http://www.magtabsr.com/content/dr-resources-pdfs/Magnesium-Deficiency-A-Cause-of-Heterogenous-Disease-in-Humans.pdf
  11. Magnesium Intake and Risk of Type 2 Diabetes in Men and Women http://care.diabetesjournals.org/content/27/1/134.abstract
  12. Magnesium Intake in Relation to Systemic Inflammation, Insulin Resistance, and the Incidence of Diabetes http://care.diabetesjournals.org/content/33/12/2604.abstract?ijkey=f923c1120dc6636d93fa39d29c797bee45949288&keytype2=tf_ipsecsha
  13. Dietary magnesium intake is inversely associated with serum C-reactive protein levels: meta-analysis and systematic review. http://www.ncbi.nlm.nih.gov/pubmed/24518747
  14. Magnesium Ascorbyl Phosphate Regulates the Expression of Inflammatory Biomarkers in Cultured Sebocytes http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4530145/
  15. Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women.  http://www.ncbi.nlm.nih.gov/pubmed/17413107
  16. Magnesium intake and plasma concentrations of markers of systemic inflammation and endothelial dysfunction in women. http://www.ncbi.nlm.nih.gov/pubmed/17413107
  17. Glutathione Biosynthesis.  https://en.wikipedia.org/wiki/Glutathione
  18. Glutathione Synthesis in Human Erythrocytes http://www.ncbi.nlm.nih.gov/pmc/articles/PMC442063/
  19. A novel missense mutation in the γ-glutamylcysteine synthetase catalytic subunit gene causes both decreased enzymatic activity and glutathione production.  http://www.bloodjournal.org/content/102/2/725?sso-checked=true
  20. Effect of membrane potential and cellular ATP on glutathione efflux from isolated rat hepatocytes. http://www.ncbi.nlm.nih.gov/pubmed/3177640
  21. Magnesium regulation of the glycolytic pathway and the enzymes involved. http://www.ncbi.nlm.nih.gov/pubmed/2931560
  22. Thiamine and magnesium deficiencies: keys to disease.  http://www.ncbi.nlm.nih.gov/pubmed/25542071
  23. THE EFFECT OF MAGNESIUM DEFICIENCY ON OXIDATIVE PHOSPHORYLATION http://www.jbc.org/content/228/2/573.full.pdf
  24. Section: “ELEMENTS OF MAGNESIUM BIOLOGY” Subsection: 1.13 Synthesis and activity of enzymes http://www.mgwater.com/durex01.shtml
  25. Magnesium metabolism. A review with special reference to the relationship between intracellular content and serum levels. http://www.ncbi.nlm.nih.gov/pubmed/3056314
  26. Antioxidative protection by melatonin: multiplicity of mechanisms from radical detoxification to radical avoidance. https://www.ncbi.nlm.nih.gov/pubmed/16217125
  27. Free radical-mediated molecular damage. Mechanisms for the protective actions of melatonin in the central nervous system. https://www.ncbi.nlm.nih.gov/pubmed/11462772
  28. Melatonin delays endoplasmic reticulum cell death in elderly patients http://www.ncbi.nlm.nih.gov/pubmed/21086186
  29. Activation of tryptophan hydroxylase by adenosine triphosphate, magnesium, and calcium. http://www.ncbi.nlm.nih.gov/pubmed/24170
  30. Activation of brain tryptophan hydroxylase by ATP-MG2+: dependence on calmodulin. http://www.ncbi.nlm.nih.gov/pubmed/6107909
  31. Dietary magnesium deficiency decreases plasma melatonin in rats. http://www.ncbi.nlm.nih.gov/pubmed/17172005
  32. The effect of melatonin, magnesium, and zinc on primary insomnia in long-term care facility residents in Italy: a double-blind, placebo-controlled clinical trial. http://www.ncbi.nlm.nih.gov/pubmed/21226679
  33. Eukaryotic DNA helicases: essential enzymes for DNA transactions. http://www.ncbi.nlm.nih.gov/pubmed/1330454
  34. DNA helicases: enzymes with essential roles in all aspects of DNA metabolism. http://www.ncbi.nlm.nih.gov/pubmed/8141804
  35. A DNA helicase from human cells.  http://www.ncbi.nlm.nih.gov/pubmed/1702201
  36. Human DNA helicase V, a novel DNA unwinding enzyme from HeLa cells.  http://www.ncbi.nlm.nih.gov/pubmed/8389437
  37. Purification and properties of human DNA helicase VI.  http://www.ncbi.nlm.nih.gov/pubmed/7543199
  38. The linkage between magnesium binding and RNA folding.  http://www.ncbi.nlm.nih.gov/pubmed/11955006
  39. Bidentate RNA-magnesium clamps: on the origin of the special role of magnesium in RNA folding. http://www.ncbi.nlm.nih.gov/pubmed/21173199
  40. A thermodynamic framework for the magnesium-dependent folding of RNA.  http://www.ncbi.nlm.nih.gov/pubmed/12717727
  41. RNA-magnesium-protein interactions in large ribosomal subunit.  http://www.ncbi.nlm.nih.gov/pubmed/22712611 
  42. A recurrent magnesium-binding motif provides a framework for the ribosomal peptidyl transferase center.  http://www.ncbi.nlm.nih.gov/pubmed/19279186
  43. DNA ligases in the repair and replication of DNA: http://www.ncbi.nlm.nih.gov/pubmed/10946235
  44. Structure and function of mammalian DNA ligases: http://www.ncbi.nlm.nih.gov/pubmed/9539976
  45. ATP-dependent DNA ligases: http://www.ncbi.nlm.nih.gov/pubmed/11983065
  46. DNA and RNA ligases: structural variations and shared mechanisms: http://www.ncbi.nlm.nih.gov/pubmed/18262407 (ATP dependent)
  47. Vitamin D in the skin physiology and pathology. http://www.ncbi.nlm.nih.gov/pubmed/26824295
  48. Expression of Inflammatory Biomarkers from Cultured Sebocytes was Influenced by Treatment with Vitamin D. http://www.ncbi.nlm.nih.gov/pubmed/23919024
  49. Vitamin D and calcium regulation of epidermal wound healing. http://www.ncbi.nlm.nih.gov/pubmed/26282157
  50. The Relationship between Ultraviolet Radiation Exposure and Vitamin D Status. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3257661/
  51. Vitamin D: The “sunshine” vitamin. http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3356951/
  52. Vitamin D Metabolism, Mechanism of Action, and Clinical Applications. http://www.sciencedirect.com/science/article/pii/S1074552114000246
  53. Cytochrome P450 enzymes in the bioactivation of vitamin D to its hormonal form (review). http://www.ncbi.nlm.nih.gov/pubmed/11172626
  54. Overview of regulatory cytochrome P450 enzymes of the vitamin D pathway.  http://www.ncbi.nlm.nih.gov/pubmed/11179747
  55. Cytochromes P450 are essential players in the vitamin D signaling system. http://www.ncbi.nlm.nih.gov/pubmed/20619365
  56. Cytochrome P450-mediated metabolism of vitamin D. http://www.ncbi.nlm.nih.gov/pubmed/23564710
  57. Consider Magnesium Homeostasis: III: Cytochrome P450 Enzymes and Drug Toxicity. http://online.liebertpub.com/doi/abs/10.1089/pai.1994.8.7

MgHealth.org 2017 Ι This website is designed by the artists at sitechild.com  Ι Contact us at info@sitechild.com